TOKYO (Reuters) - Asian shares were under pressure on Wednesday, with a rise in U.S. bond yields above the 3 percent threshold and warnings from bellwether U.S. companies of higher costs driving fears that corporate earnings growth may peak soon.

LONDON/NEW YORK (Reuters) - London-listed drugmaker Shire Plc said it was willing to recommend a deal with Takeda Pharmaceutical Co to its shareholders, after the Japanese company sweetened its acquisition offer to 46 billion pounds ($64 billion).

TIJUANA, Mexico (Reuters) - Dozens of Central American migrants from about 600 traveling in a "caravan" through Mexico arrived at the border city of Tijuana late on Tuesday despite warnings it would be futile to try to cross to claim asylum in the United States.

LONDON/NEW YORK (Reuters) - London-listed drugmaker Shire Plc said on Tuesday it was willing to recommend to its shareholders a deal with Takeda Pharmaceutical Co, after the Japanese company sweetened its acquisition offer to 46 billion pounds ($64 billion).

(Reuters) - Rapper Meek Mill, who had been incarcerated for five months on a probation violation, was released from a Pennsylvania jail on Tuesday, his attorney said, after the state's top court granted him bail, capping a star-laden campaign to have him freed.

LAGOS (Reuters) - Semi-nomadic herdsmen armed with guns killed 16 people on Tuesday in an attack on a church congregation in a central state of Nigeria plagued by communal violence, police said.

WASHINGTON (Reuters) - U.S. President Donald Trump said on Tuesday a new North American Free Trade Agreement could be agreed on quickly, as Canada hailed progress on forging new rules for the auto industry, the pivotal issue in talks to revamp the 24-year-old accord.

WASHINGTON (Reuters) - U.S. President Donald Trump's physician Ronny Jackson will continue as the nominee to lead the Veterans Affairs department after allegations about his conduct stalled his Senate hearing for the job, a White House official said on Tuesday.

WASHINGTON (Reuters) - U.S. President Donald Trump's physician Ronny Jackson will not withdraw as the nominee to head the Veterans Affairs department and will fight allegations about his conduct that surfaced ahead of a Senate confirmation hearing, a White House official said on Tuesday.

WASHINGTON (Reuters) - The U.S. Environmental Protection Agency proposed a rule on Tuesday that would limit the kinds of scientific research it can use in crafting regulations, an apparent concession to big business that has long requested such restrictions.

WASHINGTON (Reuters) - U.S. President Donald Trump on Tuesday left open the possibility that his doctor, Ronny Jackson, would withdraw as his pick to lead the Veterans Affairs department after allegations stalled his Senate confirmation hearing.

(Reuters) - London-listed drugmaker Shire Plc and Japan's Takeda Pharmaceutical Co Ltd plan to announce a preliminary deal on Wednesday, after the latter sweetened its $62 billion acquisition offer, people familiar with the matter said.

NEW YORK (Reuters) - U.S. stocks slid on Tuesday as 10-year Treasury yields hit 3 percent for the first time in four years, stoking concerns over higher borrowing rates for companies already facing rising costs, and as quarterly results failed to deliver positive outlooks.

NEW YORK (Reuters) - Bitcoin rose to a six-week high on Tuesday on positive headlines that included the possible entry of major financial institutions into the space, lifting sentiment on the overall cryptocurrency market.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk, killing 10 people, in Canada's deadliest mass killing in decades left a "cryptic message" on social media before his attack, police said on Tuesday.

WASHINGTON (Reuters) - The Environmental Protection Agency announced a new rule on Tuesday that would stop it from relying on scientific research underpinned by confidential data in its making of regulations.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk, killing 10 people, in Canada's deadliest mass killing in decades left a "cryptic message" on social media before his attack, police said on Tuesday.

WASHINGTON (Reuters) - President Donald Trump and French President Emmanuel Macron pledged on Tuesday to seek stronger measures to contain Iran, as the U.S. leader considers whether to ditch an international accord meant to prevent Tehran from obtaining a nuclear weapon.

LOS ANGELES (Reuters) - The largest U.S. manager of prescription benefits is telling drugmakers that the current pricing model is broken, and taking aim at Amgen Inc, Eli Lilly and Co and other makers of new migraine medicines to try and fix it.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk in Canada's deadliest mass killing in decades was charged with 10 counts of first-degree murder on Tuesday, as police probed what motivated his rampage.